An economical, high cost is needed in the removal process of the sodium chloride salt of the sub-reaction product caused when MCT-β-CD is manufactured.
This influences prices of manufactured goods and a big obstruction of industrial usage development.
MCT-β-CD･NaCl that omits the removal process of the sodium chloride salt is developed.
(The sodium chloride salt of about 22% is contained.)
It had comparative study of commercially available MCT-β-CD, stability, and the reactivity. It reports on the details.
Monochlorotriazino beta cyclodextrin
Product name : CAVASOL W7 MCT
MCT-β-CD・NaCl Low-cost One-Pot synthesis
As for three chloro parts (Cl) of the cyanuric chloride, the place that separates by the temperature is different.
It reacted sequentially by using this character , and MCT-β-CD･NaCl that left one Cl of the MCT group was synthesized.
Cl that remains in the MCT group covalently-immobilizes OH group of the cotton carrier fibeｒ.
Safety of commercially available MCT-β-CD
|Acute Toxicity, oral
(OECD/TG No. 401)
|rat||LD50 > 2000 mg/kg|
|Primary skin irritation
(OECD/TG No. 404)
(OECD/TG No. 406)
|guinea pig||not sensitising|
(OECD/TG No. 471)
|Salmonella typhimurium||not mutagenic|
As for MCT-β-CD･NaCl , similar safety is seen.
MCT-β-CD・NaCl quality and generic property
MCT-β-CD・NaCl Fixation method to cotton carrier fiber
MCT-β-CD・NaCl Fixation rate evaluation to cotton carrier fiber
MCT-β-CD・NaCl pH change after one year manufacturing
MCT-β-CD・NaCl A change with the lapse of time of pH of high humidity
MCT-β-CD・NaCl Clinging rate evaluation by each pH
|●||As for the fixation rate to a cotton carrier fiber that was MCT-β-CD･NaCl and commercially available MCT-β-CD it, it was an equal.|
|●||HCl separates when MCT-β-CD･NaCl is preserved in "There are neither a temperature nor a humidity control".
It is thought that the resolution is promoted by this and the pH decreases.
|When the pH is low, the a fixation rate to the cotton carrier fiber falls.
It is thought that this shows the degradation level of the quality.
|●||The examination that adds the additive (ex. sodium bicarbonate) is scheduled to be done as a method of improving the storage stability of MCT-β-CD･NaCl.|