No. 27 The Stabilization of Antioxidants by Complexation with Cyclodextrins
Ingesting of antioxidant as supplement is important for removing of reactive oxygen species which cause skin aging and some lifestyle diseases.
antioxidants
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Introduction
Polyphenol compounds are typical antioxidants. Oxidized polyphenol can react with nucleophile irreversibly. And the reaction product has a possibility of loss of it's original functions.
(R. Yoruk, et al., J. Food Biochem, 2003, 27, 361-422.)
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In this work
The stabilization of tert-butylquinone (TBQ) as a model compound of oxidized polyphenol with cyclodextrin(CDs) was explored.
![](img/research_e_027_03.png)
result
Rate constant for the unfavorable reaction of oxidized polyphenol (quinone) and nucleophile (glycine)
![](img/research_e_027_04.png)
→ CD can inhibit the unfavorable reaction of TBQ and glycine by formation of inclusion complex.
Conclusion
CDs could stabilize TBQ by formation of inclusion complex.
*rate of unfavorable reaction
withoutCD > α-CD = β-CD > γ-CD
→ This study indicated that a new general possibility of CD function. CDs show inhibitory effect to unfavorable reaction by inclusion of quinone (← polyphenol) compounds.