|Ingesting of antioxidant as supplement is important for removing of reactive oxygen species which cause skin aging and some lifestyle diseases.|
Polyphenol compounds are typical antioxidants. Oxidized polyphenol can react with nucleophile irreversibly. And the reaction product has a possibility of loss of it's original functions.
(R. Yoruk, et al., J. Food Biochem, 2003, 27, 361-422.)
In this work
The stabilization of tert-butylquinone (TBQ) as a model compound of oxidized polyphenol with cyclodextrin(CDs) was explored.
Rate constant for the unfavorable reaction of oxidized polyphenol (quinone) and nucleophile (glycine)
|→||CD can inhibit the unfavorable reaction of TBQ and glycine by formation of inclusion complex.|
CDs could stabilize TBQ by formation of inclusion complex.
＊rate of unfavorable reaction
withoutCD > αCD = βCD > γCD
|→||This study indicated that a new general possibility of CD function. CDs show inhibitory effect to unfavorable reaction by inclusion of quinone (←polyphenol) compounds.|