Recent research finding
Functinal Food Materils γCD as Majour Player

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【Purpose】

Among cyclodextrins (CDs) which are cyclic oligosaccarides, αCD, βCD and γCD are commercially available and used in Food field. Outside of cavity of CD is hydrophilic and inside is lipophilic. Based on this unique properties, CDs can include other molecule inside of cavity and make the guest molecule improve its property. Therefore, CDs has been used as supporting aides for majour player (included guest molecules).
Alpha CD and βCD can't be decomposed by enzyme very well, but γCD can be. On the other hand, its decomposition speed is lower than taking the same amount of sucrose. This means γCD can work as materials which can release glucose slowly. We focused on this property of γCD, endurance enhancement effect of γCD was researched by evaluations of maximum swimming time of mice.

Cyclodextrin (CD) ?


CD Glucose unite FW Diameter
[Å]
Solu 25℃
[g/100mL]
Crystalline water
[wt %]
Digestivity
αCD 6 972 4.7-5.3 14.5 10.2 X
βCD 7 1135 6.0-6.5 1.85 13.2-14.5 X
γCD 8 1297 7.5-8.3 23.2 8.13-17.7 O

Slow release of Gulcose by γCD


Decomposition of saccharides by amylase


Mice Swimming test

Method

Mice :Std. ddY, 6 weeks, BW35-40g, ♂
Dose :500mg/kgBW
Conditions :Flow (7L/min), Speed (19-20cm/sec), Temp (32℃)

Comparison of swimming time between glucose & γCD


Conclusion

Decomposition speed of γCD by α-amylase from pancreas (pigs) is slower than maltooctaose which has same number of glucose as γCD.
Maximum swimming time of mice was prolonged by administration of γCD.

γCD itself can work as functinal food materials.