No. 42 Inhibition effect by α-cyclodextrin on an elevation of blood glucose level after administration of sucrose

Functions of α-CD (human trial)

1. Anti-allergy
   Atopic dermatitis, Cedar pollen allergy, Asthma
2. Anti-metabolic syndrome
   Lowering effect of fat and cholesterol
   Inhibition effect to an elevation of blood glucose level
3. Regulate the functions of the intestines

Inhibition effect to an elevation of BG level by α-CD

Transition of blood glucose levels after eating boiling rice

Test material : Boiled rice contained rice (carbohydrate : 50g) and α-CD (0g, 2g, 5g, 10g)
Subjects : healthy human volunteers

Jonathan D. Buckley, Alicia A. Thorp, Karen J. Murphy, Peter R.C. Howe, Ann. Nutr. Metab., 2006, 50, 108-114.

→ α-CD can inhibit amylase activity.

Digestion of carbohydrates

In this study, inhibitory effect of α-CD on other glucosidase was explored.

Oral sucrose tolerance test (mice)

Method

1. The mice were fasted for 12 hours and administered α-CD water solution (saline for control group) orally via a stomach tube.
2. After 20 minutes, all mice group were administered sucrose water solution (2g/kgBW) orally via a stomach tube.
3. Blood sample was taken from the tail followed by measuring blood glucose level (0min, 15min, 30min, 45min and 90min).

→ These results showed that α-CD could inhibit sucrase activity.

Oral glucose tolerance test (mice)

→ These results showed that α-CD could not affect the absorption of glucose.

Conclusion

• α-CD suppressed an elevation of blood glucose level after administration of sucrose to mice.
• Inhibition of sucrase activity by α-CD was suggested.