Recent research finding
No.42 Inhibition effect by α-cyclodextrin on an elevation of blood glucose level after administration of sucrose

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Functions of αCD (human trial)

  1. Anti-allergy
    Atopic dermatitis, Cedar pollen allergy, Asthma
  2. Anti-metabolic syndrome
    Lowering effect of fat and cholesterol
    Inhibition effect to an elevation of blood glucose level
  3. Regulate the functions of the intestines

Inhibition effect to an elevation of BG level by αCD

Transition of blood glucose levels after eating boiling rice
Test material: Boiled rice contained rice (carbohydrate:50g) and αCD (0g, 2g, 5g, 10g)
Subjects: healthy human volunteers

Blood glucose level

iAUC

Jonathan D. Buckley, Alicia A. Thorp, Karen J. Murphy, Peter R.C. Howe, Ann. Nutr. Metab., 2006, 50, 108-114.

αCD can inhibit amylase activity.

Digestion of carbohydrates

In this study, inhibitory effect of αCD on other glucosidase was explored.

Oral sucrose tolerance test (mice)

Method:

1) The mice were fasted for 12 hours and administered αCD water solution (saline for control group) orally via a stomach tube.

2) After 20 minutes, all mice group were administered sucrose water solution (2g/kgBW) orally via a stomach tube.

3) Blood sample was taken from the tail followed by measuring blood glucose level (0min, 15min, 30min, 45min and 90min).

Oral sucrose tolerance test (mice)

Figure 1 Comparison of αCD dose

These results showed that αCD could inhibit sucrase activity.

Oral glucose tolerance test (mice)

Figure 2 In case of glucose instead of sucrose

These results showed that αCD could not affect the absorption of glucose.

Conclusion

αCD suppressed an elevation of blood glucose level after administration of sucrose to mice.
Inhibition of sucrase activity by αCD was suggested.