*This research was reported in 30th Cyclodextrin Symposium （Kumamoto, Sep. 12~13, 2013).
Our company have attractive technologies in functional food and personal care fields which raises the water solubility, stability and bioavailability of a functional ingredient by using the inclusion property of cyclodextrin (CD).
Ferulic acid (FA) is a kind of polyphenol contained in rice- and wheat-bran. FA as a notable anti-aging ingredient shows some health benefits. However, low aqueous solubility of FA causes low bioavailability after supplementation. So in this research, improving of water solubility of FA by CD was explored for use as high bioavailable functional health food and cosmetics material.
Ferulic Acid (FA)
: is a kind of polyphenol found in rice bran and wheat bran etc..
Anti colon cancer
Reducing of blood glucose level and blood pressure
Improving of brain function
Low aqueous solubility of FA causes low bioavailability after supplementation.
It is generally for lipophilic ingredients to be more bioavailable when they get higher aqueous solubility with some solubilizer.
→ In this study, effect of CD on aqueous solubility of FA was explored.
"αCD", "βCD", "γCD"
♦Branched-CDs：higher aqueous solubility than natural-CDs.
Phase-solubility profiles of ferulic acid with CDs.
Solubility changes of FA depending on using various types of CD.
αCD was most effective solubilizer for FA.
αCD can be a potent solubilizer for preparation of highly concentrated FA solution in water.
→ FA-αCD system can be useful for the developments of health supplements and drinks of FA with high bioavailability!