*This research was done through collaboration with Kobe University and Tokyo University of Science, and reported in 31th Cyclodextrin Symposium （Shimane, Sep. 11~12, 2014).
Our company have attractive technologies in functional food and personal care fields which raise the water solubility, stability and bioavailability of a functional ingredient by using the inclusion property of cyclodextrin (CD).
In spite of high anti-aging functions of R-α lipoic acid, its stability and bioavailability are fairly low. So some of health benefits of R-α lipoic acid can not be shown up easily. Recently, we succeeded the enhancement of bioavailability of R-α lipoic acid with γCD in rats (* please refer to the newest result of research "47th" of our homepage for details.). That effect was achieved through the stabilization of R-α lipoic acid by complexation with γCD. Therefore, we commercialized "R-α lipoic acid-γCD complex" as functional health food and cosmetics materials.
In this research, the bioavailability of R-α lipoic acid with γCD was also examined in human healthy volunteers.
Health benefits of R-α lipoic acid
*This study was approved by the ethics committees of Kobe university.
single-dose crossover comparative bioavailability trial consisted of two studies (Study 1 and Study 2) was conducted.
<Human subject> Healthy 6 males aged 20-45 years
<Test material> R-α lipoic acid -γCD ：6g (containing 600mg of R-α lipoic acid) / dose
<Comparative material> R-α lipoic acid : 600mg /dose
<Collection points of blood>
Result：Effect of γCD on the bioavailability R-α lipoic acid
Plasma concentration time-profiles of R-α lipoic acid in human healthy volunteers after oral supplementation (n=6,mean±S.D.)
Table1. Effect of γCD on the bioavailability R-α lipoic acid in human (n=6,mean±S.D.)
|Cmax (ng/mL)||AUC0→180 min
|Tmax (min)||T1/2 (min)|
|R-α lipoic acid||Mean||1678.3||78043.6||20.8||38.9|
|R-α lipoic acid-γCD||Mean||4101.9**||195884.1**||17.5||23.3|
The bioavailability of R-α lipoic acid was enhanced by complexation with γCD.
The bioavailability of R-α lipoic acid was enhanced by complexation with γCD in not only rats but also human healthy volunteers.
Any adverse effects were not shown by the single-dose of R-α lipoic acid-γCD complex.