Recent research finding
No.47 Effect of γ-cyclodextrin on absorption of R-α lipoic acid

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* This research was reported in 27th The Academy of Pharmaceutical Science and Technology (Kobe International Conference Center, Kobe, May. 24~26, 2012).

Background

Our company have the technology which raises the water solubility, stability and bioavailability of a functional ingredient by using the inclusion property of cyclodextrin (CD).

In spite of high anti-aging functions of R-α lipoic acid, its stability and bioavailability are fairly low. So some charming appeal points of R-α lipoic acid can not be shown up easily. Recently, we succeeded the stability of R-α lipoic acid was enhanced dramatically by inclusion with γCD (* please refer to the newest result of research "33rd" and the "34th" of our homepage for details.), and commercialized "R-α lipoic acid- γCD complex" as functional health food and cosmetics materials.

The low-bioavailability of R-α lipoic acid is supposed to be the cause of its low stability. So, in this research the bioavailability of R-α lipoic acid was examined in rats using the stabilized γCD complex.

Appeal points of R-α lipoic acid

Evaluation of bioavailability

< method >

animal: SD rat (8weeks, male, N=4)

Administration: Administrate histamine 1h before 20mg/kg R-α lipoic acid with p.o.

analysis: plasma concentration of R-α lipoic acid were assayed by LC-MS/MS.

Fig1 Bioavailability_result

γCD complexation improved the absorption of R(+)-α lipoic acid

Conclusions

Effect of γ-cyclodextrin on absorption of R-α lipoic acid

γCD could enhance not only the stability of R-α lipoic acid, but also bioavailability.

R-α lipoic acid –γCD complex is prospective as an excellent anti-aging functional ingredient.