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CycloChemBio Co. Ltd. was awarded a Poster Prize at 17th International Cyclodextrin Symposium

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CycloChemBio Co. Ltd. was awarded a Poster Prize at 17th International Cyclodextrin Symposium

CycloChemBio Co. Ltd. was awarded a poster prize at 17th international cyclodextrin symposium (Saarbrücken, Germany, May, 29-31, 2014). Three presentations were selected as prize winners from total 134 presentations.

<Prize winning presentation>
A Study on Inhibition Mechanism of Lipid Absorption by α-Cyclodextrin Administration

<Prize winner>
CycloChemBio Chief Researcher Takahiro Furune et al.

<Coworker>
Graduate School of Medicine, Kobe University Prof. Norihiro Sakamoto

<Abstract>
α-Cyclodextrin (αCD) has been reported as a powerful dietary fiber to reduce blood cholesterol even though αCD cannot bind to cholesterol. Thus, the mechanism of the lipid lowering effect of αCD has not been clarified. In this study, interaction of αCD and mixed micelle composed of lecithin and bile salts was explored. Mixed micelle is playing a key role of lipid solubilization in small intestine. Therefore, micellar solubility of lipids in the presence of αCD was also explored. By the addition of αCD, inclusion complex of αCD and lecithin as white solid was formed in artificial fed state intestinal juice. Furthermore, reducing of micellar solubility of lipids were also observed in the presence of αCD. These results suggested that αCD can inhibit the lipid absorption in small intestine by interaction with mixed micelle. This effect was assumed as an important part of the mechanism of the lipid lowering effect of αCD.

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<Comments of prize winner>
I'm very pleased to be awarded a poster prize at the international conference of cyclodextrin. Especially, most participants were from universities and there are only a few presentations about food chemistry. So, this winning the award is much more meaningful for us as company researchers. Daily feed intake of αCD shows some anti-metabolic syndrome effects, improvements of the intestinal environment and anti-allergy effect. In this research, we could clarified that reducing of micellar solubility of lipids by interaction between αCD and mixed micelle was important as a part of the mechanism of the lipid lowering effect of αCD. We will keep on making efforts for clarifying of the mechanisms of health enhancement effects of αCD intake on this award-winning.