Recent research finding
Effect of chain length of saturated fatty acid on interaction with α-cyclodextrin in fed-state simulated intestinal fluid

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*This research was done through collaboration with Kobe University and reported in 31th Cyclodextrin Symposium (Shimane, Sep. 11~12, 2014) and the joint conference of 8th Asian Cyclodextrin Conference and 32th Cyclodextrin Symposium (Kumamoto, May 14~16, 2015).

Background

Our company has attract attention technologies in functional food and personal care fields which raises the water solubility, stability and bioavailability of functional ingredients by using the inclusion property of cyclodextrin (CD).

Because of its high water solubility and non-digestible property, αCD can be taken as a water-soluble dietary fiber. Indeed, daily intake of αCD shows some anti-metabolic syndrome effects, improvements of the intestinal environment and anti-allergy effect. We also reported some interesting results supporting those effects (* please refer to the newest result of research "16th", "42th", "44th" and "50th" of our homepage for details.).

In this study, we report a new knowledge of αCD function on the interaction between fatty acid and αCD in fed-state simulated intestinal fluid (FeSSIF).

Functions of αCD (human trial)

  1. Anti-metabolic syndrome
    Lowering effect of fat and cholesterol
    Inhibition effect against an elevation in blood glucose level
  2. Regulation of intestinal functions
  3. Anti-allergy
    Atopic dermatitis, Cedar pollen allergy, Asthma

Present study

In our previous study, αCD showed decrease of the solubilities of fats in Fed-state simulated intestinal fluid (FeSSIF).
αCD also showed the selective decrease of the solubility of saturated fatty acid more effectively than that of unsaturated fatty acid (the newest result of research "75th" of our homepage).

In this study, effect of the chain length of saturated fatty acid on those solubility in FeSSIF in the presence of αCD was explored.

It is well known that the accumulation tendency of long chain fatty acids (> C16) is higher than that of shorter chain fatty acids (< C14) in our body.
So, we have to pay attention to take much long chain fatty acids.

Fatty acids

Saturated fatty acids

Experiment

The effects of αCD to solubilities of fatty acids in fed-state simulated intestinal fluid (FeSSIF) were explored.

Result 1
Decreasing effects of αCD on the saturated fatty acids solubilities (difference in chain length)

<Figure 1>

⋅The decreasing effect of αCD on the solubility of C18:0 was stronger than that of C16:0.
⋅The solubility of C14:0 and C12:0 were not changed by αCD.

Comparison of αCD with other dietary fibers

The decreasing effect of αCD on the solubility of Palmitic acid in FeSSIF was compared with other water soluble dietary fibers.

Water soluble dietary fibers and lipid lowering drug

⋅Resistant Maltodextrin (RM) ⋅Partially hydrolyzed (PHGG) ⋅Inulin (Inu)
⋅Polydextrose (PDX) ⋅Cholestyramine (CSA: Lipid lowering drug)

Result 2
Comparison of αCD with other dietary fibers

<Figure 2> Solubility of Palmitic acid in FeSSIF

Significant decrease of the solubility of Palmitic acid in FeSSIF was observed only in the presence of αCD.

Discussion

It is well known that absorption of fatty acids is achieved by dissolving in the small intestinal fluid.

So, from these results, αCD has a possibility on the selective inhibition of longer fatty acids (> C16) absorption relates by the decreasing of the those solubilities in the small intestinal fluid.