Recent research finding
Effect of chain length of saturated fatty acid on interaction with α-cyclodextrin in fed-state simulated intestinal fluid

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This research was done through collaboration with Kobe University and reported in the joint conference of 8th Asian Cyclodextrin Conference and 32th Cyclodextrin Symposium (Kumamoto, May 14~16, 2015).

Background

Our company has an attract attention technology in functional food and personal care fields which raises the water solubility, stability and bioavailability of functional ingredients by using the inclusion property of cyclodextrin (CD).

Because of its high water solubility and non-digestible property, αCD can be taken as a water-soluble dietary fiber. Indeed, daily feed intake of αCD shows some anti-metabolic syndrome effects, improvements of the intestinal environment and anti-allergy effect. We also reported some interesting results supporting those effects (* please refer to the newest result of research "16th", "42th", "44th" and "50th" of our homepage for details.).

In this study, we report a new knowledge of αCD function on the mechanism of selective decreasing effect on serum trans fatty acids by αCD supplementation.

Functions of αCD (human trial)

  1. Anti-metabolic syndrome
    Lowering effect of fat and cholesterol
    Inhibition effect against an elevation in blood glucose level
  2. Regulation of intestinal functions
  3. Anti-allergy
    Atopic dermatitis, Cedar pollen allergy, Asthma

Trans fatty acid

Trans fatty acid is a kind of unsaturated fatty acid generated in the production process of margarine. Natural abundance of trans fatty acid is very low. And it is well known that having too much trans fatty acid causes increase of risk of heart disease. So, we have to pay attention to take much trans fatty acids.

Under such background, selective decreasing effect on serum trans fatty acid by αCD supplementation in rats has been reported.

Selective decreasing effect on serum trans fatty acids by αCD supplementation.

Fatty acids

Experiment

The effects of αCD to solubilities of fatty acids in fed-state simulated intestinal fluid (FeSSIF) were explored.

Result Decreasing effects of αCD on the fatty acid solubility (trans vs cis)

αCD decreased the solubility of trans-fatty acid (trans-C18:1) more effectively than that of cis-fatty acid (cis-C18:1).

Discussion

It is well known that absorption of fatty acids is achieved by dissolving in the small intestinal fluid.
Hence, from these results, we consider that αCD may absorb fatty acids selectively by the decreasing the solubilities of fatty acids in the small intestinal fluid.

⇒ In the present study, we clarified the mechanisms of selective decreasing effect on serum trans fatty acid by αCD supplementation.